Acute binge alcohol consumption in a mouse model of arrhythmogenic cardiomyopathy significantly elevated ventricular arrhythmias, mortality, and myocardial fibrosis.
Does acute binge alcohol consumption increase the risk of arrhythmias, mortality, and myocardial fibrosis in a mouse model of arrhythmogenic cardiomyopathy?
Acute binge alcohol consumption exacerbates disease progression, including arrhythmias and mortality, in a mouse model of arrhythmogenic cardiomyopathy, suggesting a need for clinical awareness regarding alcohol use in ACM patients.
We report that acute binge alcohol consumption in a robust mouse model of arrhythmogenic cardiomyopathy (ACM) significantly elevated ventricular arrhythmias, mortality, cardiomyocyte cell death via the loss of nuclear HMGB1, and extensive myocardial fibrosis. These findings demonstrate that binge drinking may serve as an environmental factor that contributes to disease progression in subjects with ACM, highlighting the need for clinical awareness regarding alcohol use in this vulnerable population.
Shiel et al. (2025) studied Arrhythmogenic cardiomyopathy (ACM). Acute binge alcohol consumption was evaluated on Ventricular arrhythmias, mortality, cardiomyocyte cell death, and myocardial fibrosis. Acute binge alcohol consumption in a mouse model of arrhythmogenic cardiomyopathy significantly elevated ventricular arrhythmias, mortality, and myocardial fibrosis.