Key result
RVP-induced mechanical dyssynchrony impairs LV function and coronary flow reserve via delayed LV contraction.
Why the study?
To study the effects of mechanical dyssynchrony using a computational model coupling LV systemic circulation and coronary perfusion with flow regulation.
Does mechanical dyssynchrony associated with right ventricular pacing affect LV function and coronary flow reserve in a computational model?
Does mechanical dyssynchrony associated with right ventricular pacing affect LV function and coronary flow reserve in a computational model?
Computational modeling demonstrates that mechanical dyssynchrony, such as that caused by right ventricular pacing, significantly impacts LV function and coronary flow reserve.
RV pacing dyssynchrony may impair coronary flow reserve; leaves open clinical translation pending validation.
A computational model that couples the systemic circulation of the left ventricular (LV) and coronary perfusion with flow regulation is developed to study the effects of mechanical dyssynchrony. The delayed contraction in the LV free wall with respect to the septum has a significant effect on LV function and coronary flow reserve.
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Fan et al. (2020) studied this question. Mechanical dyssynchrony from right ventricular pacing, causing delayed left ventricular free wall contraction, significantly affects left ventricular function and coronary flow reserve.
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