Key result
Hemorrhagic shock in intact dogs altered myocardial carbohydrate metabolism and caused relative myocardial oxygen deficiency, with subendocardial hemorrhage or necrosis in some left ventricles.
Why the study?
Does hemorrhagic shock alter metabolic, hemodynamic, and pathologic parameters in the hearts of intact dogs?
Does hemorrhagic shock alter metabolic, hemodynamic, and pathologic parameters in the hearts of intact dogs?
Hemorrhagic shock induces significant metabolic alterations, oxygen deficiency, and structural damage in the canine myocardium.
May indicate myocardial vulnerability in hemorrhagic shock; leaves open human translation and prospective validation.
The metabolic, hemodynamic and pathologic effects of hemorrhagic shock on the hearts of intact dogs have been studied, using the technique of venous catheterization of the coronary sinus. Metabolic studies demonstrated an alteration in the pattern of myocardial carbohydrate metabolism during shock and evidence for a relative myocardial oxygen deficiency. Subendocardial hemorrhage or necrosis was found in the left ventricles of some of the dogs.
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Hackel et al. (1955) studied Hemorrhagic shock. Hemorrhagic shock was evaluated on Metabolic, hemodynamic and pathologic effects on the heart. Hemorrhagic shock in intact dogs altered myocardial carbohydrate metabolism and caused relative myocardial oxygen deficiency, with subendocardial hemorrhage or necrosis in some left ventricles.
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