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OBJECTIVES: The aim of this retrtospective study was to investigate the association between undernutrition and the trajectories of neurocognitive aging. METHODS: We used harmonized data from two population-based longitudinal studies: the Progetto Veneto Anziani and the Italian Longitudinal Study on Aging. Both studies included a baseline and two follow-up evaluations over 9 y. Undernutrition was defined according to the Global Leadership Initiative on Malnutrition criteria, and cognitive function was assessed using the Mini-Mental State Examination. RESULTS: The analytical sample comprised 3852 individuals (46% female) aged 65 to 96 y. During follow-up, growth mixture modeling identified three Mini-Mental State Examination score trajectories. Trajectory 1 (4.8% of participants) was characterized by a steep decline, trajectory 2 (22.1% of participants) by a gradual decrease, and trajectory 3 (73.1% of participants) by high scores that remained nearly stable throughout the follow-up period. Overall, 540 participants (14.1%) had undernutrition, with a prevalence significantly higher in trajectory 1 (26.9%) than in trajectory 2 (17.3%) or trajectory 3 (12.2%). Baseline undernutrition was associated with a higher probability of belonging to the rapidly decreasing trajectory 1 (odds ratio, 1.71, 95% confidence interval, 1.06-2.77, reference, trajectory 3), a finding driven mainly by the phenotypic Global Leadership Initiative on Malnutrition criteria. CONCLUSIONS: Undernutrition is associated with steeper cognitive decline in older adults, particularly when phenotypic signs are present. However, given the potential bidirectional relationship between cognitive status and undernutrition, reverse causation cannot be ruled out entirely. Nevertheless, our findings underscore the importance of assessing nutritional status in advanced age, as it represents a modifiable factor that may delay or prevent cognitive decline.
Ravelli et al. (Thu,) studied this question.
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