Key result
MSC-derived exosomes offer cardioprotection by regulating cardiomyocyte viability, inflammation, angiogenesis, and remodeling.
Mesenchymal stem cell-derived exosomes show potential for cardiac function repair and clinical application in cardiovascular diseases through various cardioprotective mechanisms.
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Should not change clinical practice in cardiovascular disease; leaves open translation of exosome efficacy to randomized trials.
Exosomes, mainly derived from mesenchymal stem cells, provide a good reference for cardiac function repair and clinical application in cardiac and vascular diseases by regulating cardiomyocyte viability, inflammatory levels, angiogenesis, and ventricular remodeling after a heart injury. This review presents the cardioprotective efficacy of mesenchymal stem cell-originated exosomes and explores the underlying molecular mechanisms. Furthermore, we expound on several efficient approaches to transporting exosomes into the heart in clinical application and comment on the advantages and disadvantages of each method.
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Zhang et al. (2023) conducted a review in cardiovascular diseases. mesenchymal stem cell-derived exosomes was evaluated. Mesenchymal stem cell-derived exosomes demonstrate cardioprotective efficacy in cardiovascular diseases by regulating cardiomyocyte viability, inflammation, angiogenesis, and ventricular remodeling.
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