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October 29, 1999Science

The Presenilins in Alzheimer's Disease--Proteolysis Holds the Key

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Authors

Christian Haass
Christian HaassInje University
Bart De Strooper
Bart De StrooperUniversity of London

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Cite This Study

Haass et al. (1999) studied this question.

synapsesocial.com/papers/6a0da01fcae7912d2fa52243https://doi.org/10.1126/science.286.5441.916
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment1997 · 77 citations
  2. 2Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons1998 · 358 citations
  3. 3<i>Notch1</i> is required for the coordinate segmentation of somites1995 · 857 citations
  4. 4Expression of Alzheimer’s Disease-associated Presenilin-1 Is Controlled by Proteolytic Degradation and Complex Formation1998 · 197 citations