Key result
Streptozotocin-induced diabetes imposed greater stress on interfibrillar mitochondria than subsarcolemmal mitochondria, with increased superoxide generation (P<0.01) and oxidative damage.
Population
Swiss-Webster mice
Comparison
Intraperitoneal injections of streptozotocin to… vs Citrate saline vehicle
Design
Preclinical
Follow-up
5 weeks
Authors
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Does not support clinical practice changes; leaves open whether targeting interfibrillar mitochondria alters diabetic cardiomyopathy progression.
Diabetes mellitus disproportionately impairs interfibrillar mitochondria in the heart, contributing to the pathogenesis of diabetic cardiomyopathy.
Dabkowski et al. (2008) studied Diabetic cardiomyopathy. Streptozotocin vs. Citrate saline vehicle was evaluated on Mitochondrial function, morphology, and oxidative damage in subsarcolemmal vs interfibrillar subpopulations. Streptozotocin-induced diabetes imposed greater stress on interfibrillar mitochondria than subsarcolemmal mitochondria, with increased superoxide generation (P<0.01) and oxidative damage.
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