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February 1, 1982Journal of Biological ChemistryOpen Access

Hamster cardiomyopathy. A defect in oxidative phosphorylation in the cardiac interfibrillar mitochondria.

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Key result

Cardiomyopathic hamsters exhibit a mitochondrial oxidative defect characterized by significantly decreased state 3 ADP-stimulated respiration confined wholly to the interfibrillar mitochondria.

Authors

CHCharles L. HoppelBTBernard TandlerWPWilliam Parland

Discussion

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Overview

Subcellular enzyme shifts in BIO 14.6 hamsters are hypothesis-generating; clinical translation to cardiomyopathy remains unproven.

PICO

P
Population
Cardiomyopathic (BIO 14.6) hamsters compared to controls to determine oxidative defects in cardiac tissue and subcellular organelles.
E
Exposure / Comparator
Cardiomyopathy (BIO 14.6 strain) vs Normal hamster hearts (controls)
O
Primary Outcome
State 3 ADP-stimulated respiration in interfibrillar mitochondria

Cite This Study

Hoppel et al. (1982) studied Cardiomyopathy. Cardiomyopathy (BIO 14.6 strain) vs. Normal hamster hearts (controls) was evaluated on State 3 ADP-stimulated respiration in interfibrillar mitochondria. Cardiomyopathic hamsters exhibit a mitochondrial oxidative defect characterized by significantly decreased state 3 ADP-stimulated respiration confined wholly to the interfibrillar mitochondria.

synapsesocial.com/papers/6a618107dcbd73a1130a674ehttps://doi.org/10.1016/s0021-9258(19)68226-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Depressed Fatty Acid and Acetate Oxidation and Other Metabolic Defects in Homogenates from Hearts of Hamsters with Hereditary Cardiomyopathy1974 · 26 citations
  2. 2Defective Oxidative Phosphorylation in Hereditary Myocardiopathy in the Syrian Hamster1968 · 38 citations
  3. 3Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation2008 · 373 citations
  4. 4Myocardial subcellular fractionation studies on cardiomyopathic Syrian hamsters1979 · 13 citations
  5. 5Cardiomyopathic and healthy acidotic hamster hearts: mitochondrial activity may regulate cardiac performance1986 · 41 citations