Why the study?
Does verapamil improve metabolic and functional derangements in 180-200-day-old cardiomyopathic Syrian hamsters?
Population
180-200-day-old cardiomyopathic Syrian hamsters and age-matched healthy animals
Comparison
Verapamil for 24 hours vs Untreated cardiomyopathic hamsters and normal…
Design
Preclinical
Follow-up
24 hours
Authors
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Hypothesis-generating for verapamil in hereditary cardiomyopathy; human studies needed before clinical consideration.
Does verapamil improve metabolic and functional derangements in 180-200-day-old cardiomyopathic Syrian hamsters?
Acute verapamil therapy improves mitochondrial function, left ventricular pressure, and coronary flow in a Syrian hamster model of hereditary cardiomyopathy.
Markiewicz et al. (1986) studied this question.
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