Key result
Myopathic Syrian hamsters show increased 5'-nucleotidase activity and sarcolemma equilibrium density compared to controls.
Why the study?
The effects of hereditary cardiomyopathy on myocardial subcellular organelles and membrane composition in Syrian hamsters without ventricular hypertrophy or heart failure were unclear.
Population
Syrian hamsters with hereditary cardiomyopathy without ventricular hypertrophy or overt heart failure and control animals
Comparison
Myopathic hamsters vs control animals
Design
Analytical subcellular fractionation and enzymic microanalysis of myocardial homogenates
Authors
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Suggests primary sarcolemmal membrane defect in hamster cardiomyopathy; hypothesis-generating with no current clinical implications.
Subcellular fractionation in cardiomyopathic hamsters reveals sarcolemmal abnormalities, suggesting a primary defect in membrane composition as the underlying abnormality.
Fitchett et al. (1979) studied Hereditary cardiomyopathy. Hereditary cardiomyopathy vs. Control animals was evaluated on Subcellular organelle characteristics (5'-nucleotidase activity and equilibrium density). Myopathic Syrian hamsters showed highly significant increases in 5'-nucleotidase activity and increased equilibrium density of the sarcolemma compared to controls.
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