Why the study?
Does D-600 treatment prevent the shift of alpha to beta isomyosin in cardiomyopathic Syrian hamsters?
Population
Cardiomyopathic UM-X7.1 Syrian hamsters and normal hamsters
Comparison
D-600 treatment vs Untreated myopathic hamsters
Design
Preclinical
Authors
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Hypothesis-generating dissociation of necrosis prevention from isomyosin shift in hamster cardiomyopathy; leaves open independent mechanistic roles.
Does D-600 treatment prevent the shift of alpha to beta isomyosin in cardiomyopathic Syrian hamsters?
In a hamster model of cardiomyopathy, D-600 prevents necrotic lesions but does not alter the shift from alpha to beta isomyosin, suggesting the shift is unrelated to necrosis.
Jasmin et al. (1988) studied this question.
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