Key result
The presence of the Kv beta 2.1 subunit altered hKv1.5 alpha subunit function, shifting activation and inactivation midpoints to -14.1 mV and -22.1 mV and increasing slow inactivation 1.5-fold.
Population
Mammalian cell lines (HEK 293 and mouse L-cells) expressing hKv1.5 alpha subunit
Comparison
Presence of Kvbeta2.1 subunit vs Absence of Kvbeta2.1 subunit (HEK 293 cells alone)
Design
Preclinical
Authors
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May influence Kv1.5 data from heterologous systems; leaves open its role in native cardiac channels.
The Kvbeta2.1 subunit alters Kv1.5 alpha subunit function, explaining functional differences observed between different heterologous expression systems.
Uebele et al. (1996) studied this question. Kv beta 2.1 subunit co-expression vs. Absence of Kv beta 2.1 subunit was evaluated on Midpoints for activation and inactivation of hKv1.5. The presence of the Kv beta 2.1 subunit altered hKv1.5 alpha subunit function, shifting activation and inactivation midpoints to -14.1 mV and -22.1 mV and increasing slow inactivation 1.5-fold.
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