Key result
Photoactivation of rose bengal drastically inhibited Kv1.3, Kv1.4, Kv1.5, Kv3.4, and IRK3 channels, while tert-butyl hydroperoxide removed fast inactivation of Kv1.4 and Kv3.4.
Population
Native K+ channels from T lymphocytes and K+ channels cloned from cardiac, brain, and T-lymphocyte cells…
Comparison
Exposure to reactive oxygen species generators vs Unexposed channels or comparison between…
Design
Preclinical
Authors
Loading...
ROS modification of K+ channels may promote ischemia-reperfusion arrhythmias; hypothesis-generating for human translation.
Different types of cloned and native K+ channels show distinct susceptibilities to modification by reactive oxygen species, potentially contributing to dysrhythmias during ischemia and reperfusion.
Duprat et al. (1995) studied Oxidant stress on K+ channels. Reactive oxygen species (photoactivation of rose bengal, tert-butyl hydroperoxide, xanthine/xanthine oxidase) was evaluated on Channel activity and fast inactivation processes. Photoactivation of rose bengal drastically inhibited Kv1.3, Kv1.4, Kv1.5, Kv3.4, and IRK3 channels, while tert-butyl hydroperoxide removed fast inactivation of Kv1.4 and Kv3.4.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: