Population
Isolated ventricular myocytes from ICR mice hearts
Comparison
Oxygen free radicals generated by mixing… vs Control conditions and in the presence of OFR…
Design
Preclinical
Authors
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OFR-KATP reactivation may promote ischemia-reperfusion arrhythmias; hypothesis-generating in mouse myocytes and leaves open human translation.
Oxygen free radicals increase KATP channel activity in mouse cardiac myocytes, which may contribute to arrhythmogenesis during ischemia-reperfusion.
Park et al. (2003) studied this question.
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