What question did this study set out to answer?

To determine the direct effects of exogenous oxygen free radicals, generated by xanthine and xanthine oxidase, on myocardial contractility and cardiovascular hemodynamics.

April 1, 1993Angiology

Cardiac Depressant Effects of Oxygen Free Radicals

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Why the study?

Does exogenous oxygen free radical generation decrease cardiac contractility in isolated rabbit hearts and anesthetized dogs?

Population

Isolated perfused heart of rabbit and anesthetized dogs

Comparison

Exogenous oxygen free radicals generated by… vs Baseline or absence of OFR/SOD

Design

Preclinical

Authors

KPKailash PrasadCross-Cutting Cardiology JKJawahar KalraSaskatchewan Health Authority LBLalita BharadwajUniversity of Saskatchewan

Discussion

Member takes

Implication

Hypothesis-generating for OFR-mediated contractile dysfunction; leaves open scavenger benefit in human ischemia-reperfusion.

Key Points

To determine the direct effects of exogenous oxygen free radicals, generated by xanthine and xanthine oxidase, on myocardial contractility and cardiovascular hemodynamics.
Evaluated myocardial contractility in isolated perfused rabbit hearts exposed to xanthine and xanthine oxidase in the presence or absence of the radical scavenger superoxide dismutase.
Measured hemodynamic variables and myocardial contractility indices in anesthetized dogs following the systemic administration of xanthine or xanthine oxidase.
Oxygen free radicals generated concentration-dependent reductions in left ventricular contractility in isolated rabbit hearts, which were completely prevented by superoxide dismutase administration.
Xanthine oxidase administration in anesthetized dogs significantly reduced mean aortic pressure, cardiac index, heart rate, and left ventricular contractility while increasing systemic and pulmonary vascular resistance.

Structured PICO

Does exogenous oxygen free radical generation decrease cardiac contractility in isolated rabbit hearts and anesthetized dogs?

Population

Isolated perfused heart of rabbit and anesthetized dogs

Intervention

Exogenous oxygen free radicals (OFR) generated by xanthine plus xanthine oxidase, with or without superoxide dismutase (SOD)

Comparator

Baseline or absence of OFR/SOD

Outcome

Cardiac contractility and hemodynamic parameters (left ventricular contractility, mean aortic pressure, left ventricular work index, heart rate, cardiac index, left ventricular systolic pressure, left ventricular end-diastolic pressure, dp/dt)surrogate

Oxygen free radicals act as cardiac depressants, decreasing cardiac function and contractility in preclinical models, suggesting a potential role for OFR scavengers in clinical conditions with increased OFR production.

Cite This Study

Prasad et al. (1993) studied this question.

synapsesocial.com/papers/6a8b1de59ac394ad33caa613 https://doi.org/10.1177/000331979304400401

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Cardiac Depressant Effects of Oxygen Free Radicals

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiac Depressant Effects of Oxygen Free Radicals

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider