Why the study?
Does superoxide dismutase therapy reduce reperfusion injury in animal models of myocardial ischemia?
Population
Animal models (dog, rat, rabbit) of myocardial ischemia and reperfusion
Design
Review
Authors
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Reduces arrhythmias and stunning but not infarct size in animal models; leaves open clinical translation of antioxidant therapy.
Does superoxide dismutase therapy reduce reperfusion injury in animal models of myocardial ischemia?
While superoxide dismutase and other antioxidants can reduce reperfusion-induced arrhythmias and stunning in animal models, they do not prevent irreversible myocardial infarction.
Downey et al. (1991) studied this question.
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