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March 1, 1986AJP Heart and Circulatory Physiology

Beneficial actions of superoxide dismutase and catalase in stunned myocardium of dogs

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Authors

GGG. J. GrossHospital for Sick ChildrenNFNeil E. FarberMarquette UniversityHHHarold F. HardmanMarquette University

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Implication

Controlled animal study demonstrates improved subendocardial function following ischemia and reperfusion in dogs, indicating oxygen radicals contribute to reversible myocardial injury.

Key Points

  • To determine whether scavenger enzymes superoxide dismutase and catalase reduce reversible myocardial dysfunction (myocardial stunning) induced by brief coronary occlusion and subsequent reperfusion.
  • Barbital-anesthetized dogs were subjected to 15 minutes of coronary artery occlusion followed by 3 hours of reperfusion.
  • Treated animals received left atrial infusions of superoxide dismutase plus catalase (SOD + CAT) starting 30 minutes before and lasting throughout occlusion, compared against a control group.
  • Subendocardial percent segment shortening (%SS) was measured using sonomicrometry, and regional myocardial blood flow was quantified with radioactive microspheres.
  • Subendocardial percent segment shortening in the ischemic territory was significantly higher in the SOD plus CAT group than in controls during occlusion and throughout reperfusion (P < 0.05).
  • Hemodynamic measurements and regional myocardial blood flow showed no significant differences between the SOD plus CAT-treated dogs and the control dogs.

Cite This Study

Gross et al. (1986) studied this question.

synapsesocial.com/papers/6a726d28abc331a85807bca4https://doi.org/10.1152/ajpheart.1986.250.3.h372
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Superoxide dismutase reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs.1989 · 129 citations
  2. 2Superoxide Dismutase Therapy for Myocardial Ischemia1991 · 65 citations
  3. 3Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia.1985 · 323 citations
  4. 4Sustained Limitation by Superoxide Dismutase of Canine Myocardial Injury Due to Regional Ischemia Followed by Reperfusion1988 · 76 citations
  5. 5Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.1984 · 908 citations