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January 1, 1989Circulation

Superoxide dismutase reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs.

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Why the study?

Does superoxide dismutase reduce reperfusion arrhythmias, improve regional function, and reduce tissue necrosis in conscious dogs after coronary occlusion and reperfusion?

Population

Conscious dogs subjected to 90-minute coronary artery occlusion and reperfusion, studied 3-4 weeks after…

Comparison

Superoxide dismutase and catalase, or… vs Control group

Design

Preclinical

Follow-up

1 week

Authors

JNJun NejimaTsurumi UniversityDKDan KnightRoyal Free London NHS Foundation TrustJFJohn T. FallonBoston University

Discussion

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Implication

rSOD attenuates reperfusion arrhythmias without infarct salvage in dogs; leaves open translation to human arrhythmia or myocardial protection.

Structured PICO

Does superoxide dismutase reduce reperfusion arrhythmias, improve regional function, and reduce tissue necrosis in conscious dogs after coronary occlusion and reperfusion?

P
Population
Conscious dogs subjected to 90-minute coronary artery occlusion and reperfusion, studied 3-4 weeks after implanting instruments
I
Intervention
Superoxide dismutase (SOD) and catalase, or recombinant SOD (rSOD) administered before and for 1 hour after coronary artery reperfusion
C
Comparator
Control group
O
Outcome
Reperfusion arrhythmias, return of regional function in ischemic myocardium, and tissue necrosis at 1 weeksurrogate

Superoxide dismutase transiently reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs.

Limitations

  • Longer periods of treatment with free radical scavengers may be required in chronic preparations

Cite This Study

Nejima et al. (1989) studied this question.

synapsesocial.com/papers/6a72b597febe604dd70abb96https://doi.org/10.1161/01.cir.79.1.143
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sustained Limitation by Superoxide Dismutase of Canine Myocardial Injury Due to Regional Ischemia Followed by Reperfusion1988 · 76 citations
  2. 2Identification of free radicals in myocardial ischemia/reperfusion by spin trapping with nitrone DMPO1987 · 361 citations
  3. 3Cardiovascular Control Mechanisms in the Conscious State1975 · 394 citations
  4. 4Influence of local anesthetics upon human polymorphonuclear leukocyte function in vitro. Reduction of lysosomal enzyme release and superoxide anion production.1977 · 134 citations