Key result
Antioxidant interventions did not alter the incidence of reperfusion-induced ventricular fibrillation compared with saline-treated controls in dogs.
Why the study?
Do antioxidant interventions prevent reperfusion-induced ventricular fibrillation in a canine model of ischemia-reperfusion?
Population
60 open-chest anesthetized dogs subjected to 15 minutes of ischemia by shunt occlusion and retrograde…
Comparison
Intravenous infusion of antioxidant… vs Intravenous saline infusion.
Design
Preclinical
Follow-up
5 minutes of reperfusion
Authors
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Antioxidant interventions in this canine model warrant clinical caution; leaves open free radical contribution to human reperfusion arrhythmias.
Do antioxidant interventions prevent reperfusion-induced ventricular fibrillation in a canine model of ischemia-reperfusion?
Antioxidant interventions do not prevent lethal reperfusion arrhythmias in a canine model, suggesting oxygen-derived free radicals do not play a primary role in this phenomenon.
David E. Euler (1995) studied Reperfusion arrhythmias (n=60). Antioxidant interventions vs. Saline was evaluated on Reperfusion-induced ventricular fibrillation. Antioxidant interventions did not alter the incidence of reperfusion-induced ventricular fibrillation compared with saline-treated controls in dogs.
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