Protective effects of combined superoxide dismutase and deferoxamine on recovery of cerebral blood flow and function after cardiac arrest in dogs.

20 dogs subjected to apnea-induced cardiac arrest of 7 minutes

Combined therapy administered at the beginning of cardiopulmonary resuscitation: 1) ventilation with 100% nitrogen for 30 seconds, 2) 10 mg/kg i.a. superoxide dismutase followed by 10 mg/kg i.v. over 1 hour, and 3) 20 mg/kg i.v. deferoxamine over 1 hour

Standard treatment (n=10)

Recovery of cardiovascular variables, cerebral blood flow and oxygen consumption, and somatosensory evoked potentials 6 hours after resuscitationsurrogate