Why the study?
Does the combination of hSOD and catalase improve postischemic segmental shortening in rabbit hearts?
Population
Open-chest anesthetized rabbits with xanthine oxidase-deficient hearts undergoing 20-minute left coronary…
Comparison
Combination of human recombinant superoxide… vs hSOD alone or catalase alone
Design
Preclinical
Follow-up
Acute
Authors
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Preserves postischemic function only with combined hSOD and catalase in rabbits; leaves open translation to human myocardial recovery.
Does the combination of hSOD and catalase improve postischemic segmental shortening in rabbit hearts?
In a rabbit model of ischemia-reperfusion, combined free-radical scavenging with hSOD and catalase preserves myocardial wall motion, suggesting free radicals contribute to postischemic dysfunction.
Matsuki et al. (1990) studied this question.
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