Why the study?
Does administration of superoxide dismutase and catalase prevent cardiac dysfunction and Na+,K+-ATPase inhibition in stunned rabbit hearts?
Population
Isolated Langendorff-perfused rabbit hearts subjected to 15 min of global normothermic ischemia followed by…
Comparison
Superoxide dismutase and catalase administered… vs Untreated ischemic reperfused hearts
Design
Preclinical
Follow-up
10 min reperfusion
Authors
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Does not support SOD plus catalase for stunned rabbit hearts; leaves open oxidative mechanisms in clinical ischemia/reperfusion injury.
Does administration of superoxide dismutase and catalase prevent cardiac dysfunction and Na+,K+-ATPase inhibition in stunned rabbit hearts?
Antioxidant enzymes SOD and catalase do not protect against ischemia/reperfusion-induced cardiac dysfunction or Na+,K+-ATPase inhibition in a rabbit model of myocardial stunning.
Kaplán et al. (2008) studied this question.
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