Novel Myofilament Ca 2+ -Sensitizing Property of Xanthine Oxidase Inhibitors
Population
Right ventricular trabeculae dissected from rat hearts subjected to 20 minutes global ischemia and reperfusion
Comparison
Allopurinol and mercaptopropionylglycine… vs No drugs (stunned group) and nonischemic controls
Design
Preclinical
Follow-up
20 minutes of reflow
Authors
Discussion
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Member takes
Implication
Caution against clinical use in stunned myocardium; hypothesis-generating for myofilament Ca2+ sensitization in ischemia-reperfusion.
Structured PICO
P
Population
Right ventricular trabeculae dissected from rat hearts subjected to 20 minutes global ischemia and reperfusion (model of myocardial stunning)
I
Intervention
Allopurinol (xanthine oxidase inhibitor) and mercaptopropionylglycine (MPG), allopurinol alone, or oxypurinol (100 micromol/L)
C
Comparator
No drugs (stunned group) and nonischemic controls
O
Outcome
Isovolumic developed pressure recovery, [Ca2+]i, and contractile forcesurrogate
Allopurinol and oxypurinol act as novel inotropic agents by sensitizing cardiac myofilaments to calcium, preserving contractility in stunned myocardium.
Cite This Study
Pérez et al. (1998) studied this question.