Key result
Allopurinol treatment significantly improved the recovery of left ventricular developed pressure to 97% of baseline compared to 88% in untreated controls after global myocardial ischemia.
Why the study?
Does allopurinol improve ATP levels and functional recovery in isolated rat hearts after global myocardial ischemia?
Does allopurinol improve ATP levels and functional recovery in isolated rat hearts after global myocardial ischemia?
Absolute Event Rate: 97% vs 88%
p-value: p=<0.05
Allopurinol protects globally ischemic myocardium and improves functional recovery by enhancing the salvage of hypoxanthine for reincorporation into adenine nucleotides, rather than solely preventing oxygen free radical formation.
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May improve post-ischemic LV recovery in rat hearts; leaves open clinical translation.
Lasley et al. (1988) studied Global myocardial ischemia (n=18). Allopurinol vs. Untreated control was evaluated on Recovery of left ventricular developed pressure at 60 minutes of reperfusion (% of baseline) (p=<0.05). Allopurinol treatment significantly improved the recovery of left ventricular developed pressure to 97% of baseline compared to 88% in untreated controls after global myocardial ischemia.
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