Why the study?
Does intravenous allopurinol prevent reperfusion injury in a canine model of coronary artery occlusion?
Population
Dogs undergoing 40-min coronary artery occlusion and reperfusion
Comparison
Allopurinol 1 mg/kg and 10 mg/kg intravenously vs Control zone and dose comparison
Design
Preclinical
Authors
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Hypothesis-generating for allopurinol in canine reperfusion; should not yet change clinical practice.
Does intravenous allopurinol prevent reperfusion injury in a canine model of coronary artery occlusion?
In a canine model, allopurinol facilitated the washout of adenine nucleotide breakdown products during reperfusion, suggesting protection against ischemia-reperfusion injury.
Кузьмин et al. (1995) studied this question.
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