Why the study?
Does allopurinol pretreatment improve postischemic cardiac function and alter purine washout profiles in isolated rabbit and rat hearts?
Population
Isolated rabbit and rat hearts subjected to 1 h of global ischemia at 27 or 37 degrees C
Comparison
Brief pretreatment with 100 microM allopurinol vs No allopurinol pretreatment
Design
Preclinical
Authors
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Species-specific allopurinol effects in isolated hearts warrant clinical caution; leaves open xanthine oxidase inhibition as a human ischemia-reperfusion target.
Does allopurinol pretreatment improve postischemic cardiac function and alter purine washout profiles in isolated rabbit and rat hearts?
The cardioprotective effect of allopurinol via xanthine oxidase inhibition is species-dependent, being effective in rats but not in rabbits, suggesting xanthine oxidase is not a universal contributor to cardiac ischemic damage.
Grum et al. (1987) studied this question.
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