Key result
Allopurinol significantly depressed the apoptosis index and expression of Fas and Caspase-3 in the non-infarcted zones of rats after myocardial infarction compared with the MI group.
Why the study?
Does allopurinol reduce cardiomyocyte apoptosis in rats after myocardial infarction?
Population
Rat model of myocardial infarction induced by ligation of the anterior descending coronary artery
Comparison
Allopurinol 50 mg/kg/day for 28 days vs Myocardial infarction group and sham operation…
Design
Preclinical, Randomly divided into three groups
Follow-up
28 days
Authors
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No practice change from rat data; leaves open translation of apoptosis reduction to human remodeling.
RCT
randomly divided
Does allopurinol reduce cardiomyocyte apoptosis in rats after myocardial infarction?
Allopurinol may inhibit cardiomyocyte apoptosis and attenuate ventricular remodeling after myocardial infarction in rats by reducing reactive oxygen species.
Xiao et al. (2009) conducted an RCT in Myocardial infarction. Allopurinol vs. MI group and sham operation group was evaluated on Apoptosis index and expression of Fas and Caspase-3 in non-infarcted zones. Allopurinol significantly depressed the apoptosis index and expression of Fas and Caspase-3 in the non-infarcted zones of rats after myocardial infarction compared with the MI group.
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