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March 1, 2000Antioxidants and Redox Signaling

Oxygen Free Radicals and Excitation-Contraction Coupling

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Population

Multicellular and isolated single-cell preparations of ischemic/reperfused myocardium

Design

Review

Authors

JGJoshua I. GoldhaberCedars-Sinai Smidt Heart InstituteMQMohammed QayyumKing Khalid University

Discussion

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Overview

Oxidative mechanisms in I/R injury identify therapeutic targets; leaves open whether modulating these pathways improves clinical outcomes.

Structured PICO

P
Population
Multicellular and isolated single-cell preparations of ischemic/reperfused myocardium
I
Intervention
Oxygen free radicals (OFR)
O
Outcome
Mechanisms of contractile failure, rigor, and calcium overload

Oxygen free radicals cause myocardial injury during ischemia/reperfusion through metabolic impairment and direct alteration of calcium handling proteins like the SR Ca2+ pump and NaCaX.

Cite This Study

Goldhaber et al. (2000) studied this question.

synapsesocial.com/papers/6a75b2dcae41e4ffbd6a3adchttps://doi.org/10.1089/ars.2000.2.1-55
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selective Effects of Oxygen Free Radicals on Excitation-Contraction Coupling in Ventricular Muscle1996 · 151 citations
  2. 2Oxygen free radicals and cardiac reperfusion abnormalities.1992 · 194 citations
  3. 3Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle. Implications for ischemia and reperfusion injury.1989 · 141 citations
  4. 4Hydroxyl Radical Inhibits Sarcoplasmic Reticulum Ca<sup>2+</sup>-ATPase Function by Direct Attack on the ATP Binding Site1997 · 270 citations
  5. 5Glycolytic inhibition and calcium overload as consequences of exogenously generated free radicals in rabbit hearts.1991 · 113 citations