Population
Intact cardiac myocytes isolated from control and rapid pacing-induced heart failure dog hearts
Comparison
Exposure to exogenous hydroxyl radical… vs Control dog heart myocytes
Design
Preclinical
Authors
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May indicate intrinsic oxidative vulnerability in failing myocytes; leaves open human translation and therapeutic targeting.
Failing cardiac myocytes demonstrate a greater intrinsic susceptibility to oxidative stress-induced cellular injury compared to normal myocytes, independent of antioxidant defense levels.
H Tsutsui (2001) studied this question.
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