Key result
Exposure of isolated adult rat ventricular myocytes to oxygen free radicals caused cellular injury and contractile abnormalities due to increased calcium influx through voltage-gated calcium channels.
Why the study?
Does exposure to oxygen free radicals cause cardiac myocyte injury and calcium overload in isolated adult rat ventricular myocytes?
Does exposure to oxygen free radicals cause cardiac myocyte injury and calcium overload in isolated adult rat ventricular myocytes?
Oxygen free radicals induce cardiac myocyte injury and calcium overload via voltage-gated calcium channels, leading to energy depletion and cell death.
No takes yet. Share an insight, caveat, or question.
Radical-induced calcium overload may injure myocytes; hypothesis-generating in rats, leaves open human relevance.
Josephson et al. (1991) studied Myocardial injury and cellular calcium overload. H2O2 and Fe3(+)-nitrilotriacetate was evaluated on Cellular injury, contractile abnormalities, and calcium loading. Exposure of isolated adult rat ventricular myocytes to oxygen free radicals caused cellular injury and contractile abnormalities due to increased calcium influx through voltage-gated calcium channels.
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