A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasation

Y Ikeda; Makoto Kondō; Jun‐ichi Suehiro; Hiroko Oshima; Sau Yee Kok; Kazuki Takahashi; Joris Pauty; Dong Wang; Hiroyuki Sakurai; Tetsuro Watabe; Masanobu Oshima; Yukiko T. Matsunaga

doi:10.1016/j.isci.2025.112517

April 24, 2025iScienceOpen Access

A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasation

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Key Points

To investigate the biological and physical mechanisms regulating the intravasation of circulating tumor cell clusters using an engineered tumor-microvessel platform.
Engineered a microfluidic tumor-microvessel-on-a-chip system to mimic the tumor-vascular interface.
Modeled and visualized the dynamics of circulating tumor cell (CTC) cluster escape across endothelial barriers.
Identified mechanical and cellular processes that drive cancer cell clusters to enter microvessels as cohesive units.
Provided an in vitro screening framework capable of testing anti-metastatic therapeutic strategies that inhibit CTC cluster dissemination.

Implication

In vitro microfluidic study reveals mechanisms of cancer cell cluster intravasation, indicating therapeutic opportunities to suppress tumor metastasis.

Abstract

system can be used to develop therapeutic strategies for tumor metastasis by targeting the release of CTC clusters.

Discussion

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Cite This Study

Ikeda et al. (2025) studied this question.

synapsesocial.com/papers/6a0da388fb8c7be8ffba7735 https://doi.org/10.1016/j.isci.2025.112517

View Full Paper

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A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasation

Key Points

Implication

Abstract

Discussion

Cite This Study

A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasation

Key Points

Implication

Abstract

Discussion

Cite This Study

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