What question did this study set out to answer?

To evaluate the immunogenicity, presentation mechanisms, and T-cell receptor recognition of novel influenza-derived peptides restricted to the common HLA-B*18:01 molecule.

January 1, 2024Clinical & Translational ImmunologyOpen Access

Characterisation of novel influenza‐derived HLA‐B*18:01‐restricted epitopes

View Full Paper

Ask AI

Bookmark

Authors

SLSamuel Liwei LeongLa Trobe University LMLawton D. MurdoloLa Trobe University JMJanesha C. MaddumageLa Trobe University

Discussion

Member takes

Implication

Laboratory study reveals novel immunogenic influenza-derived peptides presented by HLA-B*18:01 in human immune cells, highlighting new targets for broad CD8+ T cell-mediated vaccines.

Key Points

To evaluate the immunogenicity, presentation mechanisms, and T-cell receptor recognition of novel influenza-derived peptides restricted to the common HLA-B*18:01 molecule.
Assessed the immunogenicity and binding restriction of six mass-spectrometry-identified influenza peptides in HLA-B*18:01-positive individuals using CD8+ T cell activation assays and protein biochemistry.
Determined high-resolution crystal structures of HLA-B*18:01 bound to immunogenic influenza peptides using X-ray crystallography and sequenced peptide-specific TCR repertoires.
Three of the six novel candidate peptides elicited CD8+ T cell responses and demonstrated confirmed HLA-B*18:01 restriction across multiple individuals.
Structural analysis yielded the first crystal structures of HLA-B*18:01 presenting immunogenic influenza peptides alongside private, restricted TCR repertoires against all evaluated epitopes.

Cite This Study

Leong et al. (2024) studied this question.

synapsesocial.com/papers/6a0da61788250cfcc2a50bff https://doi.org/10.1002/cti2.1509

View Full Paper

Ask AI

Bookmark

Implication

Laboratory study reveals novel immunogenic influenza-derived peptides presented by HLA-B*18:01 in human immune cells, highlighting new targets for broad CD8+ T cell-mediated vaccines.

Characterisation of novel influenza‐derived HLA‐B*18:01‐restricted epitopes

Discussion

Member takes

Implication

Key Points

Cite This Study

Characterisation of novel influenza‐derived HLA‐B*18:01‐restricted epitopes

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider