Key result
MyoD expression in muscle plasticity is highly muscle-specific and varies over time and between species, preventing universally valid predictions for its regulation.
This review highlights the complex, context-dependent role of MyoD in skeletal muscle plasticity across different conditions like exercise, disuse, and denervation.
MyoD should not guide universal predictions in muscle plasticity; leaves open context-specific investigations across species and conditions.
The myogenic regulatory factor MyoD plays an important role in embryonic and adult skeletal muscle growth. Even though it is best known as a marker for activated satellite cells, it is also expressed in myonuclei, and its expression can be induced by a variety of different conditions. Several model systems have been used to study the mechanisms behind MyoD regulation, such as exercise, stretch, disuse, and denervation. Since MyoD reacts in a highly muscle-specific manner, and its expression varies over time and between species, universally valid predictions and explanations for changes in MyoD expression are not possible. This review explores the complex role of MyoD in muscle plasticity by evaluating the induction of MyoD expression in the context of muscle composition and electrical and mechanical stimulation.
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Legerlotz et al. (2008) conducted a review in Muscle plasticity. MyoD expression in muscle plasticity is highly muscle-specific and varies over time and between species, preventing universally valid predictions for its regulation.
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