Key result
Ectopic expression of MyoD in the developing mouse heart leads to abnormal heart morphology, death, and activation of skeletal muscle-specific genes.
Population
Transgenic mice expressing MyoD in the developing heart
Design
Preclinical
Authors
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Raises possibility of MyoD involvement in congenital heart defects; leaves open translation from mouse models.
Ectopic expression of MyoD in the developing mouse heart is sufficient to activate the skeletal muscle differentiation program in vivo, leading to abnormal cardiac morphology and death.
Miner et al. (1992) studied Transgenic mice. Ectopic MyoD expression was evaluated on Phenotypic and molecular changes in the heart. Ectopic expression of MyoD in the developing mouse heart leads to abnormal heart morphology, death, and activation of skeletal muscle-specific genes.
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