Why the study?
Does ectopic expression of myf5 induce myogenic differentiation in vivo in transgenic mice?
Population
Transgenic mice harboring the bovine homolog, bmyf, under control of the murine sarcoma virus promoter
Design
Preclinical
Authors
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Ectopic myf5 induces myogenic conversion in murine heart and brain; extends myogenic determination research but leaves open clinical translation.
Does ectopic expression of myf5 induce myogenic differentiation in vivo in transgenic mice?
Ectopic expression of myf5 in transgenic mice initiates myogenic differentiation in vivo, supporting its role in determining cells to the myogenic lineage during embryogenesis.
Santerre et al. (1993) studied this question.
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