What question did this study set out to answer?

This research investigates the timing and location of myf-5 expression during mouse embryogenesis.

April 1, 1991Development

Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo

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Population

Mouse embryos

Design

Preclinical

Authors

MOMarie‐Odile OttEuropean Council EBEva BoberMax Planck Institute for Heart and Lung Research GLGary E. LyonsCross-Cutting Cardiology

Discussion

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Implication

Distinguishes skeletal from cardiac myogenic programs in mice; leaves open relevance to human congenital muscle disorders.

Key Points

This research investigates the timing and location of myf-5 expression during mouse embryogenesis.
In situ hybridization was used to analyze myf-5 expression in mouse embryos.
Expression was monitored in somites, dermomyotome, visceral arches, and limb buds.
The study tracked the levels of myf-5 transcripts over key stages of embryonic development.
Myf-5 expression was first detected in somites at approximately 8 days post-conception (p.c.).
Expression precedes that of myogenin and MyoD1, indicating early involvement in muscle cell development.
Myf-5 transcripts decrease significantly after 11.5 days p.c., becoming undetectable by 14 days p.c.

Structured PICO

Population

Mouse embryos

Intervention

In situ hybridization to detect myf-5 expression

Outcome

Expression pattern of myf-5 during embryogenesis

myf-5 is expressed early in skeletal muscle precursor cells during mouse embryogenesis, preceding other myogenic regulatory sequences, suggesting a role in myogenic lineage determination.

Cite This Study

Ott et al. (1991) studied this question.

synapsesocial.com/papers/6a206d2fddea50bfc43d206a https://doi.org/10.1242/dev.111.4.1097

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Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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