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July 1, 1996Molecular and Cellular BiologyOpen Access

Distinct Regulatory Elements Control Muscle-Specific, Fiber-Type-Selective, and Axially Graded Expression of a Myosin Light-Chain Gene in Transgenic Mice†

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Population

Transgenic mice and transfected cells

Comparison

Mutated transgenes containing MLC1f promoter and… vs Complete transgene

Design

Preclinical

Authors

MRMala V. RaoMDMaria J. DonoghueJMJohn P. Merlie

Discussion

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Overview

Preclinical mapping of MLC1f enhancer elements leaves open human therapeutic translation; extends cis-regulatory insights in animal models.

Structured PICO

P
Population
Transgenic mice and transfected cells
I
Intervention
Mutated transgenes containing MLC1f promoter and downstream enhancer
C
Comparator
Complete transgene
O
Outcome
Transgene activity and expression patterns (muscle-specific, fiber-type-selective, and axially graded expression)surrogate

The study identifies at least nine distinct regulatory sites that control the levels and patterns of MLC1f expression in adult muscles.

Cite This Study

Rao et al. (1996) studied this question.

synapsesocial.com/papers/6a87c52b6e1dca10b7bb58b3https://doi.org/10.1128/mcb.16.7.3909
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modular elements of the MLC 1f/3f locus confer fiber-specific transcription regulation in transgenic mice1996 · 19 citations
  2. 2Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in transgenic mice.1995 · 241 citations
  3. 3Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene.1992 · 137 citations
  4. 4A Skeletal Muscle-Specific Enhancer Regulated by Factors Binding to E and CArG Boxes Is Present in the Promoter of the Mouse Myosin Light-Chain 1A Gene1995 · 91 citations
  5. 5Functional activity of the two promoters of the myosin alkali light chain gene in primary muscle cell cultures: comparison with other muscle gene promoters and other culture systems1988 · 75 citations