Population
Transgenic mice containing lacZ under transcriptional control of the mouse MLC3F promoter and 3' enhancer…
Comparison
Transgene expression (MLC3F-lacZ) vs Endogenous MLC3F promoter expression
Design
Preclinical
Authors
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Highlights compartment-specific transcription in mice; challenges uniform cardiac regulation models but remains hypothesis-generating.
The MLC3F regulatory sequences direct regionalized expression in both skeletal and cardiac muscle in transgenic mice, revealing transcriptional differences between left and right heart compartments.
Kelly et al. (1995) studied this question.
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