Key result
A combination of positive (HF-1a/HF-1b) and negative (E-box and HF-3) regulatory elements is required to maintain ventricular chamber-specific expression of the MLC-2v gene in vivo.
Population
Transgenic mice harboring mutations in putative MLC-2 cis regulatory elements in a 250-bp MLC-2-luciferase…
Design
Preclinical
Authors
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Should not yet change clinical practice; leaves open whether these elements regulate ventricular genes in humans.
A combination of positive (HF-1a/HF-1b) and negative (E-box and HF-3) regulatory elements are required to maintain ventricular chamber-specific expression of the MLC-2v gene in vivo.
Lee et al. (1994) studied Ventricular chamber-specific gene expression. Mutations in HF-1, HF-2, E-box, and HF-3 regulatory elements was evaluated on Ventricular chamber-specific expression of the MLC-2v gene (luciferase reporter activity). A combination of positive (HF-1a/HF-1b) and negative (E-box and HF-3) regulatory elements is required to maintain ventricular chamber-specific expression of the MLC-2v gene in vivo.
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