Key result
The upstream stimulating factor (USF) binds to MLE1, HF-1a, and PRE B sites, positively and negatively regulating the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements.
Population
Transgenic mice and primary cultured neonatal rat myocardial cells
Design
Preclinical
Authors
Loading...
Hypothesis-generating for cardiac gene regulation; leaves open effects on human ventricular function or disease.
The basic helix-loop-helix protein USF regulates the cardiac ventricular myosin light-chain 2 gene through independent cis regulatory elements, providing insight into cardiac muscle-specific gene expression.
Navankasattusas et al. (1994) studied Cardiac gene regulation. Upstream stimulating factor (USF) was evaluated on Protein-DNA interaction and transcriptional activation of MLC-2v gene. The upstream stimulating factor (USF) binds to MLE1, HF-1a, and PRE B sites, positively and negatively regulating the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: