Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 1, 1999Journal of VirologyOpen Access

The V Protein of Simian Virus 5 Inhibits Interferon Signalling by Targeting STAT1 for Proteasome-Mediated Degradation

View Full Paper
Ask AI
Bookmark
Share

Key result

Simian virus 5 (SV5) and its structural protein V block interferon signalling in human cells by specifically targeting STAT1 for proteasome-mediated degradation.

Population

human cells

Design

Preclinical

Follow-up

up to 4 days postinfection

Authors

LDL. DidcockUniversity of St AndrewsDYD. F. YoungUniversity of St AndrewsSGStephen GoodbournSt George's, University of London

Discussion

Loading...

Member takes

Overview

May inform interferon restoration strategies; hypothesis-generating from animal models.

Structured PICO

P
Population
human cells
I
Intervention
Simian virus 5 (SV5) infection or expression of SV5 structural protein V
O
Outcome
Inhibition of interferon signalling and degradation of STAT1surrogate

SV5 evades the host antiviral response by specifically degrading STAT1, a critical component of interferon signaling.

Cite This Study

Didcock et al. (1999) studied Viral infection. Simian virus 5 (SV5) / V protein was evaluated on STAT1 degradation and inhibition of IFN signalling. Simian virus 5 (SV5) and its structural protein V block interferon signalling in human cells by specifically targeting STAT1 for proteasome-mediated degradation.

synapsesocial.com/papers/6a0dad2f88250cfcc2a512fahttps://doi.org/10.1128/jvi.73.12.9928-9933.1999
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.1989 · 376 citations
  2. 2Cyclic AMP response element-binding protein and the catalytic subunit of protein kinase A are present in F9 embryonal carcinoma cells but are unable to activate the somatostatin promoter.1992 · 68 citations
  3. 3Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis1997 · 524 citations