What question did this study set out to answer?

To review the incidence trends, prevalence, transmission patterns, and clinical burden of hepatitis C virus infection in the United States.

December 1, 1997HepatologyOpen Access

Epidemiology of hepatitis C

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Authors

MAM J AlterMcGill University

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Implication

Epidemiological analysis reveals declining acute hepatitis C cases alongside substantial chronic liver disease burden in the United States, highlighting a major reservoir for ongoing transmission.

Key Points

To review the incidence trends, prevalence, transmission patterns, and clinical burden of hepatitis C virus infection in the United States.
Analyzed national surveillance data to evaluate temporal trends in acute hepatitis C virus (HCV) incidence from the mid-1980s through 1995.
Assessed seroprevalence of antibodies to HCV (anti-HCV), associated chronic liver disease mortality, and risk exposure profiles across demographic groups.
Annual acute HCV infections declined from an estimated 180,000 cases in the mid-1980s to 28,000 in 1995, with 25% to 30% presenting as clinically apparent, symptomatic illness.
Anti-HCV prevalence in the general population was 1.8% (approximately 3.9 million individuals), leading to an estimated 8,000 to 10,000 annual deaths from chronic liver disease.
Transmission mechanisms shifted from historical blood transfusions to high-risk drug and sexual exposures, with peak incidence and prevalence rates concentrated in non-white racial/ethnic groups and young adults.

Cite This Study

M J Alter (1997) studied this question.

synapsesocial.com/papers/6a0dad2f88250cfcc2a512ff https://doi.org/10.1002/hep.510260711

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December 1, 1997HepatologyOpen Access

Epidemiology of hepatitis C

View Full Paper

Ask AI

Bookmark

Authors

MAM J AlterMcGill University

Discussion

Member takes

Implication

Epidemiological analysis reveals declining acute hepatitis C cases alongside substantial chronic liver disease burden in the United States, highlighting a major reservoir for ongoing transmission.

Key Points

To review the incidence trends, prevalence, transmission patterns, and clinical burden of hepatitis C virus infection in the United States.
Analyzed national surveillance data to evaluate temporal trends in acute hepatitis C virus (HCV) incidence from the mid-1980s through 1995.
Assessed seroprevalence of antibodies to HCV (anti-HCV), associated chronic liver disease mortality, and risk exposure profiles across demographic groups.
Annual acute HCV infections declined from an estimated 180,000 cases in the mid-1980s to 28,000 in 1995, with 25% to 30% presenting as clinically apparent, symptomatic illness.
Anti-HCV prevalence in the general population was 1.8% (approximately 3.9 million individuals), leading to an estimated 8,000 to 10,000 annual deaths from chronic liver disease.
Transmission mechanisms shifted from historical blood transfusions to high-risk drug and sexual exposures, with peak incidence and prevalence rates concentrated in non-white racial/ethnic groups and young adults.

Cite This Study

M J Alter (1997) studied this question.

synapsesocial.com/papers/6a0dad2f88250cfcc2a512ff https://doi.org/10.1002/hep.510260711

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