Key result
Non-invasive cepstral analysis of internal carotid wave speed correlates strongly with the foot-to-foot method.
Why the study?
Local wave speed provides an objective analysis of cardiovascular function, motivating a novel non-invasive method to determine it in the internal carotid artery at only one site.
Does a novel non-invasive method using cepstral analysis accurately estimate local wave speed in the internal carotid artery compared to the foot-to-foot method in healthy subjects?
Cross-Sectional (n=22)
Does a novel non-invasive method using cepstral analysis accurately estimate local wave speed in the internal carotid artery compared to the foot-to-foot method in healthy subjects?
Effect estimate: R2=0.72
A novel non-invasive method using cepstral analysis of single-site blood velocity waveforms accurately estimates local wave speed in the internal carotid artery.
Cepstral analysis may enable single-site carotid wave speed estimation; leaves open prospective validation in patients before clinical adoption.
Objectives Local wave speed is a biomarker which provides an objective analysis of the cardiovascular function. The aim of this study was to determine the local wave speed in the internal carotid artery by a new non-invasive method that measures blood velocity waveform at only one site. Methods For this purpose, the cepstral analysis was employed to determine the arrival time of the reflection wave and the wave speed in the carotid artery. To validate our model, we applied it experimentally in vivo on young and old healthy subjects. The blood velocity waveform was measured by using phase-contrast magnetic resonance for 22 subjects. Results Our experimental results correlated with reference values reported in previous studies conducted on the internal arterial carotid usually adopting the invasive method. They also correlated with those obtained by using the foot-to-foot method (R2=0.72). The wave speed obtained by the method developed in this study and that of the foot-to-foot method increased with age (p<0.001). Conclusions The method developed in this study can be applied in the other arteries and it can also be used with other techniques such as ultrasound imaging.
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Ayadi et al. (2020) conducted a cross-sectional in Healthy subjects (n=22). Cepstral analysis of blood velocity waveform vs. Foot-to-foot method was evaluated on Correlation of local wave speed with foot-to-foot method (R2=0.72). A novel non-invasive method using cepstral analysis to estimate local wave speed in the internal carotid artery correlated with the foot-to-foot method (R2=0.72) and increased with age (p<0.001).
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