Key result
Phase-contrast cardiovascular magnetic resonance wave intensity analysis showed patients with coronary heart disease had higher wave speed (9.5 vs 5.8 m/s) than healthy volunteers.
Why the study?
Can wave intensity analysis be feasibly and reproducibly derived from ultrahigh temporal resolution PC-CMR to detect differences between healthy individuals and patients with coronary heart disease?
Population
30 participants, comprising 15 healthy volunteers and 15 patients with coronary heart disease.
Comparison
Wave intensity analysis derived from very high… vs Healthy volunteers compared to patients with…
Design
Cross-sectional
Authors
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Detects vascular stiffness differences in CHD via PC-CMR wave intensity analysis; leaves open clinical utility pending prospective validation.
Cross-Sectional (n=30)
No
Can wave intensity analysis be feasibly and reproducibly derived from ultrahigh temporal resolution PC-CMR to detect differences between healthy individuals and patients with coronary heart disease?
Absolute Event Rate: 9.5% vs 5.8%
p-value: p=<0.0001
A novel, semi-automated PC-CMR method for wave intensity analysis is feasible, reproducible, and can detect vascular stiffness and compromised ventricular function in patients with coronary heart disease.
Biglino et al. (2012) conducted a cross-sectional in Coronary heart disease (n=30). Wave intensity analysis using phase-contrast cardiovascular magnetic resonance vs. Healthy volunteers was evaluated on Wave speed (c) in m/s (p=<0.0001). Phase-contrast cardiovascular magnetic resonance wave intensity analysis showed patients with coronary heart disease had higher wave speed (9.5 vs 5.8 m/s) than healthy volunteers.
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