Key result
A newly designed mock circulatory system demonstrated flow sensitivity to preload and afterload and the effect of test fluid (water vs pig blood) on the hemodynamic performance of the Medos VAD.
A newly designed mock circulatory system effectively characterizes the hydraulic performance of ventricular assist devices under varying conditions.
Mock circulatory loops aid VAD hydraulic testing; extends preclinical methods but leaves clinical translation open.
A new mock circulatory system (MCS) was designed to evaluate and characterise the hydraulic performance of ventricular assist devices (VADs). The MCS consists of a preload section and a multipurpose afterload section, with an adjustable compliance chamber (C) and peripheral resistor (R p ) as principal components. The MCS was connected to a pulse duplicator system for validation, simulating a wide range of afterload conditions. Both pressure and flow were measured, and the values of the different components calculated. The data perfectly fits a 4-element electrical analogon (EA). The MCS was further used to assess the hydrodynamic characteristics of the Medos VAD as an example of a displacement pump. Data was measured for various MCS settings and at different pump rates, yielding device specific pump function graphs for water and pig blood. Our data demonstrate (i) flow sensitivity to preload and afterload and (ii) the effect of test fluid on hemodynamic performance.
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Vandenberghe et al. (2001) studied Ventricular assist device evaluation. Mock circulatory system (MCS) testing of Medos VAD was evaluated on Hydrodynamic characteristics (pressure and flow). A newly designed mock circulatory system demonstrated flow sensitivity to preload and afterload and the effect of test fluid (water vs pig blood) on the hemodynamic performance of the Medos VAD.
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