Two brothers with polycythemia rubra vera have been studied: one before treatment and one after many years of treatment. Direct harvests of marrow aspirates from both patients exhibited the presence of the Ph1 chromosome. Moderately increased LAP levels were present in both. Available data do not indicate whether the disease and the chromosomal aberrations in these two brothers are familial or fortuitous.
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Levin et al. (1967) studied this question.
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