The Effect of Treatment in Patients with Chronic Myelogenous Leukemia

Article1 November 1963The Effect of Treatment in Patients with Chronic Myelogenous LeukemiaBiochemical StudiesJEROME B. BLOCK, M.D., PAUL P. CARBONE, M.D., JOOST J. OPPENHEIM, M.D., MIL FREI III, M.D.JEROME B. BLOCK, M.D.Search for more papers by this author, PAUL P. CARBONE, M.D.Search for more papers by this author, JOOST J. OPPENHEIM, M.D.Search for more papers by this author, MIL FREI III, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-5-629 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe circulating leukocytes of patients with chronic myelogenous leukemia (CML) have decreased or absent leukocyte alkaline phosphatase (LAP) activity (1-3). Recently, it has been shown that these leukocytes have a high intracellular hydrogen ion concentration (4, 5) and diminished leukocyte acid excretion when compared with leukocytes from patients without hematologic disease (5-7). The relative effects of several chemotherapeutic agents on the magnitude and duration of response of hematologic and cytogenetic abnormalities in patients with CML have been presented in the preceding paper by Carbone et al. (8) in this issue of the ANNALS. The present report describes the effects of...References1. WACHESTEIN M: Alkaline phosphatase activity in blood and bone marrow cells. J. Lab. Clin. Med. 31: 1, 1946. MedlineGoogle Scholar2. VALENTINEBECK WNWS: Biochemical studies on leukocytes. I. Phosphatase activity in health, leukocytosis and myelocytic leukemia. J. Lab. Clin. Med. 38: 38, 1951. Google Scholar3. WILTSHOWMOLONEY EWC: Histochemical and biochemical studies on leukocyte alkaline phosphatase activity. Blood 10: 1120, 1955. 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GOMORI G: Histochemical demonstration of phosphatase in tissue sections. Proc. Soc. Exp. Biol. Med. 42: 23, 1939. CrossrefGoogle Scholar11. WADDELLBUTLER WSTC: Calculations of intracellular pH from the distribution of 5,5-dimethyl-2, 4-oxazolidinedione (DMO) application to skeletal muscle of the dog. J. Clin. Invest. 38: 720, 1959. CrossrefMedlineGoogle Scholar12. IRVINESAUNDERSMILNECRAWFORD ROSSMDNA: Gradients of potassium and hydrogen ion in potassium deficient voluntary muscle. Clin. Sci. 20: 1, 1961. MedlineGoogle Scholar13. MORSEBRONSONKLIMANFREIREICHCARBONE EEWBAEJPP: Repeat plasmophoresis of donors with chronic leukemia as a source of granulocytes. Manuscript in preparation. Google Scholar14. FALLONFREIDAVIDSONTRIERBURKE HJEJDJSD: Leukocyte preparations from human blood: Evaluation of their morphologic and metabolic state. J. Lab. Clin. Med. 59: 779, 1962. MedlineGoogle Scholar15. 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TRUBOWITZKIRMANMASEK SDB: The leukocyte alkaline phosphatase in mongolism. Lancet 2: 486, 1962. CrossrefMedlineGoogle Scholar21. KINGGILLISBAIKIE MJEMAG: The polymorphalkaline phosphatase in mongolism. Lancet 2: 661, 1962. CrossrefGoogle Scholar22. FITZGERALDADAMSGUNZ PHAW: Chronic granulocytic leukemia and the Philadelphia chromosome. Blood 21: 183, 1963. CrossrefMedlineGoogle Scholar23. HUGULEYGRIZZLERUNDLESBELLCORLEYFROMMEYERGREENBERGHAMMACKHERIONJAMESLARSENLOEBLEONEPALMERWILSON CMJWRWNCCWBBGWJCGWWEVLAJGSJ: Comparison of 6-mercaptopurine and busulfant in chronic myelogenous leukemia. Blood 21: 89, 1963. CrossrefGoogle Scholar24. ELLISONBURCHENAL RRJH: Treatment of chronic granulocytic leukemia with the 6-substituted purines 6-mercaptopurine, thioguanine and 6-chloropurine. Clin. Pharmacol. Ther. 1: 631, 1960. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.Requests for reprints should be addressed to Paul P. Carbone, M.D., Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda 14, Maryland. 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