Answers are grounded in this paper and cite their sources.
Chromosome studies were carried out on two occasions during the evolution of a case of acute myeloblastic leukemia. A normal karyotype was detected before treatment was started. A second analysis made while the patient was under treatment with 6-mercaptopurine showed a modal number of 44 chromosomes plus a small fragment. Apart from the abnormal karyotype, the leukemic cells showed a high incidence of endoreduplication and a cell with the feature of repeated endoreduplication was observed. The possible significance of these findings in acute leukemia is discussed.
No takes yet. Share an insight, caveat, or question.
Bottura et al. (1963) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: