Key result
PET molecular imaging non-invasively visualizes early myocardial fibrosis progression after MI.
Why the study?
Routine imaging modalities such as CMR and echocardiography have limited sensitivity and specificity and cannot detect early fibrosis or its activity level after myocardial infarction.
Does positron emission tomography (PET) improve the detection of early myocardial fibrosis after myocardial infarction compared to routine imaging?
Does positron emission tomography (PET) improve the detection of early myocardial fibrosis after myocardial infarction compared to routine imaging?
PET molecular imaging offers a promising non-invasive approach to detect and quantify early, reversible myocardial fibrosis after myocardial infarction, overcoming the limitations of CMR and echocardiography.
May support PET for non-invasive early post-MI fibrosis detection; leaves open prospective validation versus CMR.
Cardiac remodeling after myocardial infarction is one of the key factors affecting patient prognosis. Myocardial fibrosis is an important pathological link of adverse ventricular remodeling after myocardial infarction, and early fibrosis is reversible. Timely detection and intervention can effectively prevent its progression to irreversible ventricular remodeling. Although imaging modalities such as CMR and echocardiography can identify fibrosis, their sensitivity and specificity are limited, and they cannot detect early fibrosis or its activity level. Positron emission tomography (PET) allows non-invasive visualization of cellular and subcellular processes and can monitor and quantify molecules and proteins in the fibrotic pathway. It is valuable in assessing the extent of early myocardial fibrosis progression, selecting appropriate treatments, evaluating response to therapy, and determining the prognosis. In this article, we present a brief overview of mechanisms underlying myocardial fibrosis following myocardial infarction and several routine imaging techniques currently available for assessing fibrosis. Then, we focus on the application of PET molecular imaging in detecting fibrosis after myocardial infarction.
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Wu et al. (2024) conducted a review in Myocardial fibrosis after myocardial infarction. Positron emission tomography (PET) vs. CMR and echocardiography was evaluated. Positron emission tomography (PET) molecular imaging allows non-invasive visualization of cellular processes and is valuable in assessing early myocardial fibrosis progression after myocardial infarction.
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