Key result
CMR remains the gold standard for myocardial fibrosis while novel molecular imaging promises early detection.
Why the study?
Non-invasive imaging to assess myocardial fibrosis and guide clinical treatment is not widely available, limiting the development of innovative treatment strategies.
This review highlights the current state and recent advances in multimodality imaging, particularly CMR, echocardiography, and nuclear medicine, for the non-invasive assessment of myocardial fibrosis.
Continue using CMR for fibrosis assessment clinically; leaves open validation and adoption of molecular imaging techniques.
Myocardial fibrosis, a common pathophysiological consequence of various cardiovascular diseases, is characterized by fibroblast activation and excessive deposition of extracellular matrix (ECM) collagen. Accumulating evidence indicates that myocardial fibrosis contributes to ventricular stiffness, systolic and diastolic dysfunction, and ultimately leads to the development of heart failure (HF). Early detection and targeted treatment of myocardial fibrosis is critical to reverse ventricular remodeling and improve clinical outcomes in patients with cardiovascular diseases. However, despite considerable progresses made in understanding molecular mechanisms of myocardial fibrosis, non-invasive imaging to assess myocardial fibrosis and guide clinical treatment is still not widely available, limiting the development of innovative treatment strategies. This review summarizes recent progresses of imaging modalities for detecting myocardial fibrosis, with a focus on nuclear medicine, echocardiography and cardiac magnetic resonance (CMR).
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Zhu et al. (2024) conducted a review in Myocardial fibrosis. Multimodality imaging (Echocardiography, CMR, CT, Nuclear Medicine) was evaluated. Cardiac magnetic resonance remains the gold standard for noninvasive detection and quantification of myocardial fibrosis, while novel molecular imaging techniques show promise for early detection.
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